SLFN 11 inhibits checkpoint maintenance and homologous recombination repair
نویسندگان
چکیده
منابع مشابه
SLFN11 inhibits checkpoint maintenance and homologous recombination repair.
High expression levels of SLFN11 correlate with the sensitivity of human cancer cells to DNA-damaging agents. However, little is known about the underlying mechanism. Here, we show that SLFN11 interacts directly with RPA1 and is recruited to sites of DNA damage in an RPA1-dependent manner. Furthermore, we establish that SLFN11 inhibits checkpoint maintenance and homologous recombination repair ...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2015
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201540964